Primary endpoints met

75% CLINICAL RESPONDERS WITH SONR SENSOR BASED OPTIMIZATION

SonR optimization is as effective as echo-guided optimization1

The RESPOND-CRT trial successfully met its primary endpoint demonstrating that automatic AV and VV optimization using the SonR contractility sensor is safe and as effective as Echo- guided AV and VV optimization.

75% of clinical responders in the SonR group versus 70% in the control group1 (p<0.001)

Results in Brief1

  • The SonRtip lead presents a very good safety profile
  • Automatic optimization with SonR is as effective as echo-guided optimization (responders 75.0% vs. 70.4%): the primary efficacy endpoint is met (p<0.001)
  • Optimization using the SonR contracility sensor shows a 35% risk reduction in HF hospitalization (p=0.01)
  • Clinical reponse for most subgroups is in favor of SonR especially in patients with a history of atrial fibrillation (22% increase in response rate) or renal dysfuction (16% increase in reponse rate)
  • For these two subgroups, SonR is associated with a risk reduction in cardiovascular death or hospitalization

SonRtip Lead Proven to be Safe

The SonRtip lead was proven to be safe, with only 1% of patients reporting lead dislodgement and 0.1% of patients reporting lead fracture.

35% Risk Reduction in HF Hospitalization1

The RESPOND-CRT landmark trial revealed that sensor-based CRT optimization with SonR is associated with a 35% reduced risk in heart failure hospitalization.

References:

  • 1. Brugada, J., P. P. Delnoy, J. Brachmann, D. Reynolds, L. Padeletti, G. Noelker, C. Kantipudi, et al. 2016. “Contractility sensor-guided optimization of cardiac resynchronization therapy: results from the RESPOND-CRT trial.” European Heart Journal 38 (10): 730-738. doi:10.1093/eurheartj/ehw526.

Back to top
Back to top

Hear from the experts

Where do we stand after two decades of trying to find the right CRT optimization strategy? Experts discuss the results of the RESPOND-CRT trial and the implications for clinical practice.

Watch the videos
Watch the videos

The Respond-CRT System™

SonR technology is available exclusively in LivaNova devices. Learn more about the Platinium SonR™ family of CRT-D devices.

Learn more
Learn more
Use of cookies

This site uses cookies. By continuing to browse the site you are agreeing to our use of cookies.

OK, I agree
OK, I agree

This site is intended for healthcare professionals outside the United States of America. By continuing to use this site you are confirming that that you are a healthcare professional based outside the USA.

Contact Us

Request brochure
Request brochure

Request brochure

To request a brochure or any other materials on RESPOND-CRT, SonR or Platinium, please fill in your details below:

Send form
Send form
Access full results
Access full results

Access full results

I would like to receive*:

Send form
Send form
Arrange presentation
Arrange presentation

Arrange presentation

To arrange a presentation of the RESPOND-CRT results by a LivaNova representative, please fill in your details below:

Send form
Send form