RESPOND-CRT Trial

A prospective, multicentre, randomized, double-blind study designed to evaluate the safety and efficacy of the SonR system.

Design

RESPOND-CRT is an International, multicenter, randomized (2:1), prospective, non-inferiority study.1

Patients

  • LVEF ≤ 35%
  • QRS ≥ 120 ms in LBBB or QRS ≥ 150 ms in non-LBBB
  • NYHA III or IV
  • Without permanent AF

Enrollment

  • 125 sites in Europe, USA, Australia
  • Jan 2012 – Oct 2014
  • Long term follow up ongoing (2 years)

Primary Efficacy Endpoint

Non-inferiority on the proportion of responders, based on a clinical composite of criteria (10% non-inferiority margin), at 12 months

Primary Safety Endpoint

Freedom from acute (0-3 months) and chronic (3-12 months) SonRtip lead complications

Secondary Endpoints

  • All-cause death or HF hospitalization
  • Worsened patients
  • Subgroups analysis on the primary efficacy endpoint

References:

  • 1. Brugada J, Brachmann J, Delnoy PP et al. Automatic optimization of cardiac resynchronization therapy using SonR-rationale and design of the Clinical trial of the SonRtip lead and Automatic AV-VV optimization Algorithm in the Paradym RF SonR CRT-D (RESPOND CRT) trial. Am Heart J , 2014 ; Vol 167 (4):429-435

Back to top
Back to top

Hear from the experts

Where do we stand after two decades of trying to find the right CRT optimization strategy? Experts discuss the results of the RESPOND-CRT trial and the implications for clinical practice.

Watch the videos
Watch the videos

The Respond-CRT System™

SonR technology is available exclusively in LivaNova devices. Learn more about the Platinium SonR™ family of CRT-D devices.

Learn more
Learn more
Use of cookies

This site uses cookies. By continuing to browse the site you are agreeing to our use of cookies.

OK, I agree
OK, I agree

This site is intended for healthcare professionals outside the United States of America. By continuing to use this site you are confirming that that you are a healthcare professional based outside the USA.

Contact Us

Request brochure
Request brochure

Request brochure

To request a brochure or any other materials on RESPOND-CRT, SonR or Platinium, please fill in your details below:

Send form
Send form
Access full results
Access full results

Access full results

I would like to receive*:

Send form
Send form
Arrange presentation
Arrange presentation

Arrange presentation

To arrange a presentation of the RESPOND-CRT results by a LivaNova representative, please fill in your details below:

Send form
Send form